Associated Press

Cardinals 41, Bills 17

GLENDALE, Ariz. -- The Bills lost their quarterback and, emphatically, their first game of the season.

Second-year quarterback Trent Edwards, a major reason Buffalo was one of three unbeaten teams entering the day, went down with a concussion on a fierce hit from safety Adrian Wilson on the third play of the game. It was the Bills' defense that collapsed after that.

Rookie Tim Hightower had a pair of touchdown runs and Kurt Warner threw to Larry Fitzgerald twice for scores. Warner, who committed six of Arizona's seven turnovers in last week's loss at the Jets, bounced back to go 33-of-42 for 250 yards with no interceptions. The Cardinals (3-2) are 3-0 at home.

Colts 31, Texans 27

HOUSTON -- Peyton Manning turned a colossal collapse by the Houston Texans into a stunning victory for the Indianapolis Colts.

The Colts scored 21 points in a late span of 2:10 -- two touchdowns thanks to fumbles by Sage Rosenfels -- then intercepted Rosenfels' last-ditch comeback attempt for a 31-27 win Sunday.

Manning threw two touchdown passes, connecting with Reggie Wayne on a 5-yarder with 1:54 remaining for the decisive points. Linebacker Gary Brackett returned a fumble by quarterback Rosenfels 68 yards for a score in between Manning's TD throws.

Broncos 16, Buccaneers 13

DENVER -- The high-flying Broncos finally discovered a defense, generating a pass rush that sent Brian Griese to the sideline with an injured throwing shoulder.

Jay Cutler guided a patient Denver offense over the Buccaneers (3-2). Brandon Stokley hauled in Cutler's pass in the right flat and followed Brandon Marshall's big block for a 10-yard touchdown and Matt Prater kicked three field goals for Denver.

Patriots 30, 49ers 21

SAN FRANCISCO -- From Randy Moss' dynamic 66-yard touchdown catch to Kevin Faulk's score on a direct snap, the Patriots returned to their usual regular-season form in an unusual place.

Faulk rushed for two scores, Matt Cassel had 259 yards passing and the Patriots won in San Francisco for the first time in franchise history.

Dolphins 17, Chargers 10

MIAMI -- The Dolphins are winning the old-fashioned way. The single wing helped build a lead, and a goal-line stand preserved it.

Ronnie Brown scored the decisive touchdown from the formation the Dolphins revived two weeks ago, their smothering defense rose to the occasion at the 1-yard line in the fourth quarter, and Miami pulled off its second successive upset.

The single wing was less explosive than in the Dolphins' win at New England, but running back Brown took a direct snap 11 times on running plays that netted 49 yards and Miami's second touchdown.

Giants 44, Seahawks 6

EAST RUTHERFORD, N.J. -- The Giants are this year's New England Patriots -- so far.

In a nearly flawless performance, Eli Manning threw two touchdowns, Brandon Jacobs ran for two more and the unbeaten Giants scored on their first five possessions.

Falcons 27, Packers 24

GREEN BAY, Wis. -- Aaron Rodgers played hurt and played hard. But he was upstaged by Matt Ryan and the Falcons.

Atlanta's rookie quarterback turned in another sharp performance, completing 16 of 26 passes for 194 yards, two touchdowns and an interception against the banged-up Packers.

Redskins 23, Eagles 17

PHILADELPHIA -- Another road win against a division opponent has the Redskins in perfect position to make a run at the NFC East.

Clinton Portis ran for 145 yards and one touchdown and wide receiver Antwaan Randle El threw a TD pass. Washington (4-1) has made it through the first five games under new coach Jim Zorn better than anyone expected. The Redskins went to Dallas last week and handed the Cowboys their first loss, 26-24. They've now played all three division rivals on the road and their next three opponents -- Cleveland, Detroit and St. Louis -- entered this week with a combined record of 1-10.

Panthers 34, Chiefs 0

CHARLOTTE, N.C. -- DeAngelo Williams had 123 yards rushing and scored three touchdowns and Panthers handed the Chiefs their first shutout in nearly six years.

The Panthers (4-1), who have missed the playoffs the past two seasons, are off to their best start since reaching the Super Bowl in the 2003 season.

Williams and Jonathan Stewart ran through a woeful defense that also couldn't stop the pass. Steve Smith caught six passes for 96 yards, Muhsin Muhammad had a 47-yard touchdown catch.

Bears 34, Lions 7

DETROIT -- Kyle Orton set career highs in yards passing, completions and quarterback rating while throwing two touchdowns. He was 24-of-34 for 334 yards and had a 121.4 rating, improving to 3-0 against the Lions.